Xingzhu Feng

Hainan Institute of Biotechnology, Haikou, 570206, Hainan, China
Author    Correspondence author
Rice Genomics and Genetics, 2025, Vol. 16, No. 6   
Received: 11 Oct., 2025    Accepted: 26 Nov., 2025    Published: 16 Dec., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Rice, as one of the most important food crops in the world, often suffers from various environmental stresses such as drought, salt stress and pathogen infection. These adverse factors seriously affect its yield and quality. This study systematically reviewed the dynamic changes of DNA methylation under adverse conditions, including methylation types such as CG, CHG, and CHH and their regulatory enzymes (such as MET1, DRM2, and CMTs), and summarized the regulatory roles of key mirnas such as miR156, miR169, and miR398 in the process of rice stress resistance. Especially in the fine regulation of transcription factors and signaling pathways, the interaction mechanism between DNA methylation and miRNA expression was analyzed with emphasis, such as the influence of methylation on the expression of miRNA gene promoters and the feedback regulation of miRNA on the expression of DNA methyltransferases. This study reveals the interaction mechanism between DNA methylation and miRNA in the stress response of rice, providing a theoretical basis and potential target resources for future molecular breeding of highly resistant rice.

Rice (Oryza sativa); DNA methylation; microRNA; Response to coercion; Epigenetic regulation